Words similar to zd
Example sentences for: zd
How can you use “zd” in a sentence? Here are some example sentences to help you improve your vocabulary:
We propose that the ZD domain interacts with the passing single-strand of DNA in the relaxation of negatively supercoiled DNA by this enzyme.
However, with the same oligonucleotide in a duplex form (Figure 3b), Top67 exhibited much higher affinity (half maximal binding value = 0.07 μM) than the ZD domain (half maximal binding value > 5 μM).
The single-strand DNA substrate designated for the ZD domain in the catalytic mechanism of the enzyme may be the strand of DNA complementary to the strand first cleaved by the enzyme to form the covalent complex.
This result indicated that with regard to the mechanism of E. coli topoisomerase I, the ZD domain was likely to function as a single-stranded DNA binding domain instead of having double-stranded DNA binding function as previously suggested [ 21 ] . Even though Zn(II) binding transcription factors that recognise specific double-stranded DNA are well represented in eukaryotes [ 23 24 ] , there are also numerous examples of Zn(II) coordination being required for interaction with single-stranded nucleic acid or damaged DNA with single-strand characteristics [ 24 25 26 27 ] .
Using purified 67 kDa transesterification domain and 30 kDa ZD domain, results from experiments described here provide new insight into the action of these two individual domains in the enzyme mechanism.