Words similar to xorphanol
Example sentences for: xorphanol
How can you use “xorphanol” in a sentence? Here are some example sentences to help you improve your vocabulary:
Competition binding studies indicated that the antagonists naltrexone, SKF 10047 and WIN 44,441 had binding affinities (K i ) in nanomolar range and the two weakest agonists, xorphanol and cyclazocine bound the receptor with the highest affinities.
This order was in agreement with the relative potencies of these drugs, showing that cyclazocine and xorphanol had higher affinities and potencies compared to morphine, although they were both less efficacious than morphine.
The rank order of affinity of the ligands was xorphanol > Win 44,441> nalorphine > morphine ≥ nalbuphine > fentanyl (Table 2).
This ligand had been described as a mixed agonist-antagonist opioid ligand [ 30 31 ] with agonistic activity at κ opioid receptors [ 32 ] . Overall very little work has been done on xorphanol and little is known about it except that it is an orally active analgesic with limited physical dependence liability [ 30 ] . Thus the present report describing its activity at δ opioid receptors provides useful data on this ligand.
Maximal inhibitory effect of each ligand was compared to the levels of maximal inhibition by β-endorphin, fentanyl, morphine and xorphanol using ANOVA analysis with Dunnett's multiple comparison as post-test using PRISM software (GraphPad Software, Inc.
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