Words similar to xorphanol
Example sentences for: xorphanol
How can you use “xorphanol” in a sentence? Here are some example sentences to help you improve your vocabulary:
The rank order of potency of the drugs studied were; etorphine > hydromorphone > dezocine > xorphanol = nalorphine = butorphanol = lofentanil > metazocine > nalbuphine > cyclazocine > fentanyl > morphine >>>> β-endorphin.
Competition binding studies indicated that the antagonists naltrexone, SKF 10047 and WIN 44,441 had binding affinities (K i ) in nanomolar range and the two weakest agonists, xorphanol and cyclazocine bound the receptor with the highest affinities.
The rank order of efficacy of the ligands tested was metazocine = xorphanol ≥ fentanyl = SKF 10047 = etorphine = hydromorphone = butorphanol = lofentanil > WIN 44,441 = Nalbuphine = cyclazocine ≥ met-enkephalin >> morphine = dezocine.
The most potent ligands studied, as measured by the lowest IC 50 values (Table 1), were etorphine, cyclazocine, lofentanil, and xorphanol with IC 50 's of less than 10 nM.
This ligand had been described as a mixed agonist-antagonist opioid ligand [ 30 31 ] with agonistic activity at κ opioid receptors [ 32 ] . Overall very little work has been done on xorphanol and little is known about it except that it is an orally active analgesic with limited physical dependence liability [ 30 ] . Thus the present report describing its activity at δ opioid receptors provides useful data on this ligand.
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