Example sentences for: xorphanol

How can you use “xorphanol” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The rank order of potency of the drugs studied were; etorphine > hydromorphone > dezocine > xorphanol = nalorphine = butorphanol = lofentanil > metazocine > nalbuphine > cyclazocine > fentanyl > morphine >>>> β-endorphin.

  • Competition binding studies indicated that the antagonists naltrexone, SKF 10047 and WIN 44,441 had binding affinities (K i ) in nanomolar range and the two weakest agonists, xorphanol and cyclazocine bound the receptor with the highest affinities.

  • The rank order of efficacy of the ligands tested was metazocine = xorphanol ≥ fentanyl = SKF 10047 = etorphine = hydromorphone = butorphanol = lofentanil > WIN 44,441 = Nalbuphine = cyclazocine ≥ met-enkephalin >> morphine = dezocine.

  • The most potent ligands studied, as measured by the lowest IC 50 values (Table 1), were etorphine, cyclazocine, lofentanil, and xorphanol with IC 50 's of less than 10 nM.

  • This ligand had been described as a mixed agonist-antagonist opioid ligand [ 30 31 ] with agonistic activity at κ opioid receptors [ 32 ] . Overall very little work has been done on xorphanol and little is known about it except that it is an orally active analgesic with limited physical dependence liability [ 30 ] . Thus the present report describing its activity at δ opioid receptors provides useful data on this ligand.


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