Words similar to xla

Example sentences for: xla

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The importance of the Tec kinases in antigen receptor signaling was first demonstrated by the observation that mutations in BTK result in the human disease X-linked agammaglobulinemia (XLA) and the murine counterpart X-linked immunodeficiency ( xid ). These severe B cell immunodeficiencies are characterized by diminished numbers of mature B cells and reduced immunoglobulin levels associated with impaired PLC-γ activation and Ca ++mobilization in response to surface IgM stimulation (sIgM) [ 8, 9, 10, 11].
Mutations in Bruton's tyrosine kinase (Btk) are responsible for the human disease termed X-linked agammaglobulinemia (XLA) (reviewed in reference [ 1]).
The B cell antigen receptor (BCR) signaling defect is very severe such that XLA patients have a block in the pro-B to pre-B cell transition and consequently have no mature B cells.
PH, pleckstrin homology; PI3K, phosphoinositide 3-Kinase; SH2, Src homology-2, SH3, Src homology-3; XLA, X-linked agammaglobulinemia; xid ; x-linked immunodeficiency; TCR, T cell receptor; sIgM, surface immunoglobulin M; (GAP), GTPase-Activating Protein; GST, Glutathione S-Transferase; SDS, Sodium Dodecyl Sulfate; PBS, phosphate buffered saline; NP40, Nonidet P-40; PAGE, polyacrylamide gel electrophoresis.
The Btk mutations found in XLA patients and the xid mouse show that Btk is required for normal B cell development, but the important pathways activated by Btk have yet to be fully identified.