Words similar to wox

Example sentences for: wox

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As summarized in Figure 1, PH-20 induces the expression of proapoptotic p53 and WOX1 [ 9 10 ] and downregulates antiapoptotic matrix inter-α-inhibitor [ 9 ] , thereby enhancing TNF susceptibility in L929 cells.
Transient expression of GFP-Hyal-1 or GFP-Hyal-2 in L929 cells induced WOX1 expression, whereas no WOX1 expression was observed in non-transfected cells or control GFP-expressing cells (Fig.
Hyal-2-increased TNF susceptibility in L929 cells appears to be associated with 1) Hyal-2 upregulation of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptotic cell death, and 3) the prolonged IκBα degradation and NF-κB activation in Hyal-2-expressing cells stimulated with TNF.
Blocking WOX1 expression with antisense mRNA abolishes p53-mediated cell death, suggesting that WOX1 is a potential partner of p53 in apoptosis [ 10 23 ] .
In comparison, the cytosolic WOX1 (46 kDa) was constitutively expressed in the L929 cells stably transfected with the GFP-Hyal-2 construct, while TNF reduced WOX1 expression in a time-dependent manner (Fig.