Words similar to wox

Example sentences for: wox

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In comparison, the cytosolic WOX1 (46 kDa) was constitutively expressed in the L929 cells stably transfected with the GFP-Hyal-2 construct, while TNF reduced WOX1 expression in a time-dependent manner (Fig.
This reduction is probably due to TNF-mediated WOX1 nuclear translocation from the mitochondria [ 10 ] . In contrast, WOX1 was not expressed in L929 cells stably transfected with the GFP-Hyal-1 construct, and TNF induced WOX1 expression in 40 min (Fig.
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
Upregulation of p53 and WOX1 contributes, in part, to the PH-20-enhanced cytotoxic function of TNF [ 9 10 23 ] . WOX1 is a p53-binding protein.
Overexpressed WOX1 alone mediates apoptosis independently of p53 [ 10 ] . However, p53 apoptosis requires the participation of WOX1.