Words similar to wox
Example sentences for: wox
How can you use “wox” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, only Hyal-2 induced WOX1 expression following stable transfection of L929 cells.
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
Overexpressed WOX1 alone mediates apoptosis independently of p53 [ 10 ] . However, p53 apoptosis requires the participation of WOX1.
Blocking WOX1 expression with antisense mRNA abolishes p53-mediated cell death, suggesting that WOX1 is a potential partner of p53 in apoptosis [ 10 23 ] .
Thus, induction of WOX1 expression contributes, in part, to Hyal-1- and Hyal-2-increased TNF sensitivity in L929 cells.
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