Words similar to word-pair
Example sentences for: word-pair
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Further improvements in the model fit (Δ R 2= 0.5% to 1.4%) were obtained using pairwise interaction terms between individual words found in the same word-pair template.
These repressed genes were enriched for rRNA processing genes, the group of genes in which this motif was originally identified [ 38 ] . Nine conserved word-pair templates contained sequences that matched most of the stress response element (STRE), the consensus site for the general stress transcription factors Msn2p/Msn4p.
Conserved word-pair templates were significantly associated with gene expression
Whereas the interaction terms only comprise a small proportion of the global variance, they can be interpreted as statistical evidence of dependence between sequence features [ 19 ] . Therefore, the nonadditive contributions of conserved word-pair templates further suggest their involvement in multifactorial regulation.
In addition to their statistical significance, many conserved word-pair templates that were most strongly associated with gene-expression changes were consistent with biological information on the transcription factors known to bind those sites [ 36 ] . In all analyses described below, we used a set of 314 word pairs that had significant associations with gene-expression changes at an FDR-corrected multiple testing threshold of p < 10 -3for five or more experiments.