Words similar to wnts

Example sentences for: wnts

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The mitogenic role played by Wnts in normal CNS development also supports the concept that the pathway could promote growth in the brain [ 21 22 ] . In order to test this hypothesis we created transgenic mice in which the Wnt pathway was aberrantly activated in the CNS.
To our knowledge this is the first report to show that two genes are differentially regulated by two different Wnts within the same cell type.
Previous reports of ectopic expression of different Wnts in C57mg cells demonstrated Wnt-1 to be highly transforming whereas Wnt-5a failed to induce transformation [ 15 16 ] . By identifying downstream targets of Wnt-5a and Rfz-2, we wanted to determine which genes are responsible for these phenotypic changes as well as which genes might be targets of noncanonical Wnt signaling.
We focused on two genes, mesothelin and SL-1, whose regulation by Wnts was reproducible using a variety of methods to activate the Wnt signaling pathways.
The Wnt/Ca 2+pathway has been shown to increase intracellular Ca 2+levels in zebrafish embryos [ 4 ] and to activate PKC and CamKII in Xenopus embryos [ 5 6 ] as well as in human melanomas [ 7 ] . Moreover, it may activate Cdc42 [ 8 ] and JNK [ 9 ] . It is important to emphasize that whether Wnts activate distinct responses and likely pathways is context-dependent, and thus in other contexts a given Wnt may activate another pathway.