Words similar to willebrand
Example sentences for: willebrand
How can you use “willebrand” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cell identity and purity was determined as previously described [ 10 ] : all cells stained (by immunofluorescence) negative for von Willebrand factor, PECAM and anti-myosin, but were positive for cytokeratin.
The ability of a MIDAS protein to bind its protein ligand is tightly linked with the presence of intact MIDAS motifs: mutations to the metal-coordinating residues in these motifs, weaken or eliminate ligand binding [ 35 36 ] . An additional set of MIDAS-like proteins, that includes the integrin β-chain [ 37 38 ] and the von Willebrand Factor A domain [ 27 ] , lacks one of the three motifs and appears to bind ligands in a somewhat different manner [ 27 39 40 ] . In midasin, the presence of all three MIDAS motifs in the M-domain, with the putative metal ion-binding residues in the motifs invariant in the available organisms, indicates that midasin belongs to the family of MIDAS-containing proteins.
Endothelin-1 is a vascular hormone, which may play a role in the generation and maintenance of heart failure [ 18 ] . In hypertensive patients, doxazosin lowers von Willebrand factor commensurate with blood pressure, but it does not lower high levels of endothelin-1 while atenolol does [ 19 ] .
vWF, von Willebrand factor
The best-studied examples of MIDAS-containing domains in other proteins are the I-domains of integrin α-chains-α1, α2, α10, and α11, and the A-domains of von Willebrand factor [ 9 25 26 27 ] . In proteins whose structure has been determined to atomic resolution, the MIDAS-containing domain has a classic Rossman-fold, with a central hydrophobic β sheet flanked on both sides by amphipathic helices.
Loading...