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Example sentences for: wilke

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As per the arguments by Wilke and Adami [ 11 ] , we expect the connectedness to decrease with d as we move away from a reference sequence in the center of a high-fitness cluster.
Wilke and Adami [ 11 ] proposed that inhomogeneities in the distribution of genotypes give rise to directional epistasis (directional epistasis is the net epistasis averaged over many pairs of mutations) among deleterious mutations, and that the sign of directional epistasis provides information about the density gradient of high-fitness sequences within a cluster.
The correlation between average mutational effects (α) and directional epistasis (β) described by Wilke and Adami [ 11 ] implies that whether a reference sequence shows synergistic or antagonistic epistasis depends on whether it lies near the center of a dense cluster of high-fitness sequences in genetic space, or on the fringes of such a cluster.
While the hypothesis of Wilke and Adami [ 11 ] explains some of the variation within the observed range of epistatic interactions, it fails to predict whether we should always expect an excess of synergistic epistasis, or whether antagonistic interactions might dominate in certain situations.