Example sentences for: wherein

How can you use “wherein” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rab proteins comprise a large family of Ras-related GTPases that function in the anterograde and retrograde trafficking of proteins in mammalian cells [ 1 2 3 ] . Different Rab proteins reside in specific subcellular membranes or organelles, where they mediate vesicular transport between discrete donor and acceptor compartments in the endocytic or exocytic pathways [ 4 5 ] . Detailed studies of a few Rab proteins ( e.g .; Rab1, Rab5 and Rab9) have led to a general model wherein Rab proteins are presumed to cycle on and off donor and acceptor membranes in connection with changes in their guanine nucleotide state [ 6 7 8 ] . In the active GTP-bound state, Rab proteins associate with budding transport vesicles [ 9 10 11 ] and appear to participate in the assembly of membrane docking complexes [ 12 13 14 ] . Following vesicle fusion with the acceptor compartment and GTP hydrolysis, the inactive GDP-bound Rab is extracted from the membrane by a carrier protein termed guanine nucleotide dissociation inhibitor (GDI) [ 15 16 17 ] . The GTPase can then re-enter the transport cycle through nucleotide exchange promoted by a specific exchange factor at the donor vesicle membrane [ 18 19 20 ] . In addition to changes in guanine nucleotide state, the posttranslational prenylation of Rab proteins plays an important role in the cycling mechanism.

  • In January 1998, LSC independently launched its state planning initiative and selected Ohio--a state wherein LSC funded 14 separate programs including two programs that served a single county--as one of its priority states.

  • Moreover, this growth response marks a difference between pheromonal acceleration of puberty in opossums and that which is well-documented in mice, wherein females paired with males ovulate at a lower body mass (< 20 g) than that of isolated females (> 20 g) [ 30 31 ] .

  • ...[H]e was indeed the glass / wherein the noble youth did dress themselves... And speaking thick, which nature made his blemish, / Became the accents of the valiant.

  • The GoCharts module graphically displays the distribution of differentially expressed genes among functional categories using the controlled vocabulary of the Gene Ontology Consortium (GO), which provides a structured language that can be applied to the functions of genes and proteins in all organisms even as knowledge continues to accumulate and change [ 13 ] . The language is structured in a directed acyclic graph (DAG), wherein term specificity increases and genome coverage decreases as one moves down the hierarchy.


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