Words similar to well-established
Example sentences for: well-established
How can you use “well-established” in a sentence? Here are some example sentences to help you improve your vocabulary:
Given the relatively late ages of first birth in this population, one might not expect to see a protective effect of having ever given birth, because the well-established protective effects of pregnancy seem to be reversed for first births at about age 30 years or later [ 21 22 ] . This study had a higher percentage of nulliparous women (25% of cases and 26% of controls) than a recent study conducted in the Seattle area (13% of cases and 14% of controls) [ 17 ] . However, the California Teachers Study cohort, with a similarly elevated rate of invasive breast cancer of 151 per 100,000 person years among non-Hispanic white women between 1995 and 1998, reported a similar percentage of nulliparous women (27%) among participants without breast cancer in 1995 [ 23 ] .
We devoutly wish that it will either disappear or quickly acquire the meaninglessness of other well-established clichés.
Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .
I think if you went around and asked any number of reasonably well-established buyout firms, they approach it the same way.
To study the molecular mechanisms underlying capillary morphogenesis in ECs, we used a well-established in vitro model of angiogenesis.
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