Example sentences for: well-defined

How can you use “well-defined” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In an effort to establish a methodological framework for analysis of the molecules and the mechanisms involved in this complex multistep process, we previously developed a well-defined experimental system in which the role of candidate genes can be screened and tested [ 2 ] . By serial dilution cloning of the MDA-MB-435 tumor cell line and screening by orthotopic implantation into the mammary fat pad of athymic mice, we derived a pair of breast tumor cell lines (M-4A4 and NM-2C5) that originate from the same breast tumor, but that have diametrically opposite metastatic capabilities.

  • It has been estimated that only 45-55% of breast cancer cases in the United States are explained by established risk factors such as income, reproductive factors, and family history [ 7 ] . Distinctive breast cancer incidence and mortality patterns in well-defined populations may therefore inform etiologic understanding.

  • The mice show systemic tolerance to Tag, mounting neither humoral nor cellular immune responses to Tag upon immunization of purified protein [ 25 26 ] . Rip1-Tag2 mice display a reproducible pattern of multistage tumor development, from normal islets to hyperplastic/dysplastic islets, to angiogenic islets, to varying grades of solid tumor, with a well-defined angiogenic progression [ 27 ] . All Rip1-Tag2 mice succumb to hypoglycemia and tumor burden by 13-16 weeks.

  • Large grants should be provided, on the basis of well-defined criteria, to only the strongest labs doing the best research.

  • Within the prison world pintos have established a well-defined and -structured social environment, which they carry to the outside world when released.


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