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Example sentences for: wedelolactone
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The in vitro myotoxicity of the crotalid venoms venoms ( Bothrops jararaca , Bothrops jararacussu and Lachesis muta ) and myotoxins (bothropstoxin, bothropasin and crotoxin) was neutralised by simultaneous exposure of isolated skeletal muscles to an aqueous extract of Eclipta prostrata or to wedelolactone, stigmaterol and sitosterol.
Stigmaterol and sitosterol were less effective than wedelolactone, but interacted synergistically with it [ 12 ] . These effects were interpreted as consequences of antiproteolytic and antiphospholipase A 2 activities of Eclipta prostrata and its constituents [ 12 ] . These three plant compounds have anti-inflammatory properties and are recognised anti-venom compounds [ 43 40 44 42 38 11 ] .
Scorpion venom when injected exerts a strong inflammatory response [ 11 ] . Many plant species used against stings contain compounds with antiinflammatory properties, flavonoids (rutin, hesperidin, quercetin), coumarins (bergapten), coumestans (wedelolactone), triterpenes, sterols and saponins [ 38 11 ] . The mechanism of action of the flavonoids is based on the inhibition of enzymatic steps in the arachidonic acid cascade [ 38 ] . Plant compounds that are immunostimulants at very low doses are some alkaloids, quinones, isobutylamides, phenolcarboxylic acid esters and terpenoids [ 39 ] . Other plant compounds with immunostimulatory effects are sesquiterpene lactones [ 40 ] . Many polysaccharides and glycoproteins enhance the unspecific immune system by activating the phagocytotic activity of granulocytes and macrophages, or by inducing cytokine production or influencing complement factors [ 39 ] .
Eclipta prostrata and its constituents (wedelolactone, stigmaterol and sitosterol) showed good potential against crotalid venoms.
injection into adult Swiss mice [ 75 12 ] . Three plant compounds, wedelolactone, sitosterol and stigmasterol were able to neutralise lethal doses of the venom.
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