Words similar to wd
Example sentences for: wd
How can you use “wd” in a sentence? Here are some example sentences to help you improve your vocabulary:
These enzymes have a conserved domain organization that includes a highly novel protein kinase catalytic domain unrelated to conventional kinases, and a carboxyl-terminal WD repeat domain that targets these enzymes to myosin II filaments (Figure 1).
A number of RING finger proteins have recently been shown to act as E3 ubiquitin ligases [ 24 ] . WD40 domains have also been frequently found in E3 complexes as substrate recruiting domains [ 25 26 27 28 ] . Despite compelling evidence from Arabidopsis implying that COP1 may mediate protein degradation [ 4 5 ] , no direct evidence of COP1 participating in ubiquitination has been reported.
Several groups of Arabidopsis mutants that are resistant to the inhibitory effects of high sugar concentrations have been isolated [ 46 47 48 49 50 ] . Characterization of these mutants reveals that the sis5 [ 46 ] , sun6 [ 50 ] , gin6 [ 49 ] and isi3 [ 45 ] mutants are allelic to the abscisic acid insensitive mutant abi4 [ 51 ] and the sis4 [ 46 ] , isi4 [ 45 ] and gin1 [ 45 ] mutants are allelic to the abscisic acid biosynthesis mutant aba2 [ 52 ] . In addition, the ethylene constitutive response mutant ctr1-1 [ 53 ] , as well as the ethylene-overproduction mutant eto1 [ 54 ] , display sugar-resistant phenotypes [ 48 ] . Conversely, the sugar-response mutant sis1 exhibits an ethylene constitutive response phenotype and is allelic to ctr1-1 [ 47 ] . The prl1 mutant, which exhibits increased sensitivity to exogenous sugars [ 55 56 ] , carries a mutation in a gene that encodes a WD protein that interacts with SNF1 protein kinases [ 57 ] .
Phosphorylated Sic1, but not the unmodified protein, is recruited to the SCF complex by binding to the WD domain of Cdc4 [ 5 ] [ 6 ] . The F-box motif of Cdc4 binds Skp1 so that the F-box protein acts as a bridge between substrate and the SCF complex.
Although we have no direct biochemical evidence to confirm this proposition, which would require Pop2p point mutants deficient in Pop1p binding, our data show that severely truncated N-terminal fragments of Pop1p and Pop2p lacking both F-boxes and WD repeat domains are sufficient to mediate their interaction (Fig.
Loading...