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For double-stranded DNA molecules, this is necessarily true because of Watson-Crick base pairing.
In th*/e "Matrix of All Possible Helices" plot http://www.rna.icmb.utexas.edu/CSI/2STR/, the same RNA sequence is extended along the X- and Y-axes, with all potential helices that are comprised of at least four consecutive Watson-Crick (G:C and A:U) or G:U base pairs shown below the diagonal line.
The Watson-Williams-Stevens test returns an F-statistic for the comparison of vectors between two groups to determine whether they represent significantly different estimates of phase (see Figures 5, 6and [ 27 32 ] for further detail).
The angle of the vector corresponds to the mean phase for the group of points, and the magnitude of the vector represents the variability in the phase estimates [ 32 ] . The Watson-Williams-Stevens statistic was applied to evaluate whether two such vectors are significantly different from one another [ 32 ] . Significant differences were evident in the phase of these two clock genes' cyclical expression under a light-dark cycle, for all tissues except isolated antennal pairs and the heads (see Figure 7) and 8.
This appears inconsistent with the revertant sequences here, which show selection for a Watson-Crick base pair at the position 3' but not 5' to the branch-point nucleotide.