Example sentences for: waf

How can you use “waf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Blots were incubated with antibodies to human cyclin H, cdk7, cyclin A, p21 WAF1/Cip1, p27 Kip1, EGFR, activated and total ERK1, c-fos, Fra-1, c-jun, JunB, or β-actin (Santa Cruz Biotechnology) for 16 hours at 4°C.

  • The genes selected for confirmation were those for cyclin D1, GADD45, GPX, HO-1, HSP70, Mdr-1, QR, prostaglandin H synthase (PGHS), p21WAF1/CIP1 and PLA2.

  • Beyond this, a marked induction of the cell cycle inhibitors p21 WAF1and p27 KIPand a decrease in PCNA expression was detectable.

  • In the cell line BxPC-3, lacking the SMAD4 gene product, the SMAD4-independent pathway can explain the TGFβ 1 sensitivity via α V β 6 integrin, the cytoskeleton and the Ras/MAP kinase pathway, resulting in an upregulation of the cell cycle inhibitiors p21/WAF1 and p27, which in turn results in the TGFβ 1 -induced growth inhibition (additional file 10).

  • Conversely, introduction of full-length BRCA1 by retrovirus-mediated gene transfer inhibited growth of breast and ovarian cancer cell lines in both in vitro and in vivo experiments [ 51], and transfection of BRCA1 into colon cancer cells inhibited new DNA synthesis by 50% in addition to inhibition of S-phase progression, possibly through direct transactivation of the cell cycle inhibitor p21 WAF1/CIP1[ 49].


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