Words similar to vr
Example sentences for: vr
How can you use “vr” in a sentence? Here are some example sentences to help you improve your vocabulary:
This construct gave rise to a high molecular weight band of 180 kDa, 20 kDa smaller than that observed for wild-type VR1 (Figure 4).
To distinguish between these possibilities, we engineered a VR1 mutant in which amino acids 2-52 in the N-terminal were deleted (termed Δ2-52).
These data indicate that wild-type VR1 channels expressed in Xenopus oocytes are present in both unglycosylated and glycosylated forms and that the N-linked glycosylation occurs at position 604.
Whereas two monomer bands had been previously observed for VR1 expressed in CHO cells [ 23 ] , a major difference between this study and ours is the difference in size between the two monomer bands (19 kDa - about five times larger than we observe).
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
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