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Example sentences for: vm

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In addition, the corresponding values of liver Vm and portal blood flow for the fed and fasting conditions are used in this simulation.
The rat liver has a number of enzymes involved in toluene metabolism [ 49 ] . Since the Km for all of these enzymes is in the mM range, while the blood toluene concentrations for this data are in the μM range, it was assumed that the metabolism is linear which, in PKQuest, is indicated by using Tclr (in place of Vm and Km).
Since liver metabolism accounts for greater than 95% of ethanol removal, it is assumed that the liver is the only site of ethanol elimination [ 19 ] . The liver metabolic constants (Vm = 2.1 millimoles/min for 80 Kg man, Km = 0.04 mM) were adjusted using the Powell minimization procedure of PKQuest to give the best fit to the data.
The FPM for this data was also estimated by using the one compartment approach [ 3 ] . Figure 5Ashows the optimized one compartment Michaelis-Menten fit to the tail of the venous ethanol data (Vm = 8.68 millimoles/min; Km = 5.46 mM).
SCm = RCm + ECm + fm * ACm + vm * ACm (2)