Words similar to vinca
Example sentences for: vinca
How can you use “vinca” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, total amounts of polymerizable tubulin are decreased in paclitaxel-resistant cells, whereas col-cemid-resistant tubulin or vinca alkaloid-resistant cells have increased levels of assembled tubulin [ 34 66 67 ] . Furthermore, when cells were transfected with β-tubulin class III, weak resistance to paclitaxel was found, and this resistance was associated with decreased microtubule stability [ 68 ] . This is consistent with the different modes of action of these drugs: paclitaxel stabilizes microtubules and colcemid inhibits tubulin assembly.
It was demonstrated that one group of antimitotic agents, vinca alkaloids, bind with similar affinity to all β-tubulin isotypes [ 12 ] , thus suggesting for therapy with vinorelbine, vinblas-tine, or vincristine that tubulin isotype levels are incidental for efficacy.
The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.
In support of this hypothesis, tubulin mutations consistent with altered assembly properties have been identified in paclitaxel-resistant and vinca alkaloid-resistant cells [ 33 66 69 ] .
Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.
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