Example sentences for: vgf
How can you use “vgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
Several of these changes are maladaptive in the sense that they contribute to the generation of the abnormal sensations that constitute neuropathic pain, by producing ectopic spontaneous activity into the CNS, altering synaptic drive, increasing excitability and diminishing inhibitory action in the dorsal horn of the spinal cord, and by making novel synaptic contacts with inappropriate neurons [ 1 4 ] . A number of the injury-regulated genes we describe here may contribute directly to this altered sensory processing; CB1 receptor, VGF, the phospholemman ion channel, SNAP25 A, endothelin-1 and the ligand-gated 5-HT3 receptor (Table 4, see additional file 3).
Neurons with axons in the peripheral nervous system can successfully regenerate when injured [ 22 ] . This is in part due to an environment permissive for axonal growth but also due to the upregulation of regeneration-associated genes (RAGs) which increase intrinsic growth capacity [ 23 ] . Three examples of RAGs are GAP-43 and CAP-23 [ 24 ] and sprp1A [ 8 ] . We now find several other potential candidates including; α2 macroglobulin, CLP36, and VGF all of which have been described to promote neurite outgrowth or interact with the cytoskeleton in a way that may promote regeneration (see Table 4 [additional file 3] for references).
Of the genes listed in Table 4, seven were found in both studies (Peripheral Benzodiazepine receptor, 5HT3, Gadd45, CLP36, Lysozyme, SNAP25 and VGF).
GTPcylo, IES-JE, CCHL2A and VGF all show a marked increase in the number of labeled neurons while SNAP25 and the 5HT3 receptor show a decrease in numbers and intensity of labeled DRG neurons following axotomy (Figure 4).
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