Words similar to versican
Example sentences for: versican
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Moreover, Frizzled receptors, Versican and other proteoglycans which contribute to Wnt protein activity are also controlled by Wnt signaling, as previously described in Drosophila [ 28 29 ] . At the level of transcriptional regulation, we found up-regulation of CBP/P300, which partners with β-catenin [ 30 31 ] but also TLE/Groucho, which is an inhibitor of TCF function [ 32 ] . These responses suggest a rich system of homeostasis and feedback control mechanisms, but they complicate the interpretation of experimental studies of Wnt signal transduction in which the time course of induction cannot be controlled easily.
Fibulin-1 has been reported to interact with such extracellular matrix proteins as fibronectin, laminin, nidogen, aggrecan and versican [ 39 40 41 42 ] . Fibronectin is a glycoprotein found as multimers in insoluble form in the extracellular matrix.
In the Wnt target gene promoters that are functionally mapped (MSX1, MSX2, ID2, ID3, Follistatin, REST/NRSF, Versican) we invariably found TCF binding sites.
For example, cadherin 13 ( CDH13 ), versican ( CSPG2 ), collagen 8A1 ( COL8A1 ), collagen 12A1 ( COL12A1 ), P4HA2 (encoding a procollagen-modifying enzyme) all showed relatively low expression in the genital skin fibroblasts of normal males, whereas tenascin XB ( TNXB ), nidogen 2 ( NID2 ), laminins ( LAMA3 , LAMA4 ) and tissue inhibitor of metalloproteinase 1 ( TIMP1 ) all showed relatively high expression levels compared to AIS-derived fibroblasts (Figure 2).
the interaction of fibulin-1C with aggrecan and versican) between extracellular matrix proteins argues for the interaction of the EGF-modules containing within fibulin-1C and LTBP-3 with either the heparin-binding region or with the EGF-like domain of HB-EGF.
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