Words similar to ventilatory
Example sentences for: ventilatory
How can you use “ventilatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
For each rat, the trachea was intubated and ventilation was maintained at a tidal volume of 2.5 ml, ventilatory frequency of 50 breaths/min, and 1 cm of positive end expiratory pressure.
Third, mismatches between the set respiratory rate and the patient's respiratory rate were not recognized, potentially prolonging the need for ventilatory support secondary to fatigue of the respiratory muscles.
Using the same ventilatory settings as in phase 1, seven inspiratory tracheal concentrations of NO, chosen according to a logarithmic scale, were randomly administered: 0.15, 0.45, 1.5, 4.5, 15, 45 and 150 ppm.
However, at analgesic doses, opioid receptor agonists or partial agonists can induce unwanted side effects such as ventilatory depression [ 1 2 ] and the development of physical tolerance and dependence [ 3 4 ] . Thus, the search for opioid ligands which possess analgesic effect and lack untoward effects has been a sought after goal of the medical community.
Our data clearly show that nalbuphine is a potent agonist at the μ opioid receptor with an efficacy similar to that of morphine, thus agreeing with in vivo data showing that morphine and nalbuphine are equally potent as analgesics [ 33 ] . However, other reports have described nalbuphine as a "mixed agonist/antagonist" with agonism at κ opioid receptors and antagonism at μ opioid receptors based on in vivo data [ 11 33 ] . This categorization is likely due to the fact that nalbuphine has been shown to reduce the ventilatory depressant effect of other opioids, while adding to their analgesic effect [ 33 ] . Nalbuphine is also used clinically to reduce the opioid-mediated side effects such as itching, without completely reversing the analgesic effects of the full agonists [ 34 35 36 ] . According to our data, although nalbuphine is clearly a potent agonist at μ receptors, its levels of agonism is significantly lower than the very efficacious drug fentanyl and the endogenous ligand β-endorphin.
Loading...