Example sentences for: vcv

How can you use “vcv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.

  • Generally, the proportion of resistant virus varied only three-fold between tests when compared to the control virus (data not shown), however a continual increase in the proportion of resistant virus was seen with the sample 30 passages (VCV treatment group).

  • As expected, a significant reduction in virus yield (greater than 3.5 log 10 decrease) was noted for mice treated with either VCV or FCV at 1.0 mg/ml following infection with either HSV-1 or HSV-2.

  • These observations can not be accounted for by differences in exposure to ACV and PCV since oral administration of VCV and FCV results in almost identical blood concentration-time curves for ACV and PCV [ 11 ] . A more probable explanation is that ACV is approximately four-fold more potent than PCV in murine cells [ 21 ] .

  • It was surprising to find that the ACV-resistant virus selected in vivo was not retained or amplified in subsequent passages despite continued suboptimal treatment with VCV.


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