Words similar to vasodilation
Example sentences for: vasodilation
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The vasodilator effect of acetazolamide on the cerebral vasculature has been characterized by both PET and transcranial Doppler (TCD) studies [ 21 22 ] . At a dose of 15 mg/kg the effect of acetazolamide is thought to be supramaximal with maximal cerebral vasodilation induced within about 20 minutes.
Biological functions attributed to NO include vasodilation [ 47], inhibition of platelet adhesion and aggregation [ 48], reduction of expression of adhesion molecules and chemokines [ 49, 50, 51, 52], and suppression of cell growth and migration [ 53, 54].
Acetazolamide, on the other hand, was hypothesized to identify areas of decreased cerebral perfusion following maximal cerebral vasodilation in Fabry disease compared to controls.
The regulation of lumenal diameter in large arteries is accomplished through the maintenance of shear stress along the arterial wall [ 38 50 51 52 53 54 ] . As blood flow through an artery increases, shear is also increased, and the endothelium releases nitric oxide for vasodilation [ 55 ] . Chronically, the arterial wall will remodel to a larger diameter to accommodate the increased flow [ 38 ] . While we did not measure arterial flow through these iron deficient arteries, the enhanced inotropic compensation to iron deficiency, combined with the enlarged aortic diameter, leads us to suspect a flow dependent mechanism for remodeling.
A prolonged half time to recovery has been associated with a decreased nitric oxide and prostanoid production [ 8 ] and a loss of endothelium dependent vasodilation [ 9 ] . Reduced vascular reactivity is associated with many diseases that are associated with aging [ 15 16 17 ] . We did not find activity effects on half time to recovery.