Words similar to vasodilation
Example sentences for: vasodilation
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The hyperemic cerebrovascular response to hypercapnia or acetazolamide is not inhibited by nitric oxide synthase inhibitors such as N G-monomethyl-L-arginine (L-NMMA) suggesting that NO does not mediate vasoreactivity [ 23 24 ] . The mechanism of acetazolamide vasodilation, beyond smooth muscle intracellular and extracellular acidosis due carbonic anhydrase inhibition, is unclear.
Inactivity has been associated with impaired efficiency of peripheral oxygen extraction [ 32 ] and reduced blood flow after cuff ischemia [ 33 ] . Conversely, exercise training results in greater maximal flow capacity [ 31 34 ] . Regular aerobic exercise also prevents the age-associated loss in endothelium dependent vasodilation maintaining maximal flow capacity [ 9 ] . Our findings support previous research that maximal flow capacity is maintained by aerobic exercise and is independent of age.
Biological functions attributed to NO include vasodilation [ 47], inhibition of platelet adhesion and aggregation [ 48], reduction of expression of adhesion molecules and chemokines [ 49, 50, 51, 52], and suppression of cell growth and migration [ 53, 54].
A prolonged half time to recovery has been associated with a decreased nitric oxide and prostanoid production [ 8 ] and a loss of endothelium dependent vasodilation [ 9 ] . Reduced vascular reactivity is associated with many diseases that are associated with aging [ 15 16 17 ] . We did not find activity effects on half time to recovery.
Altered vascular function in older individuals is evidenced as impaired endothelial function [ 8 9 10 ] , an altered ratio of endothelin receptors [ 11 ] , and/or altered reactivity of the smooth muscle to sympathetic activity [ 7 12 ] . Reduced endothelial function is related to impaired formation and decreased activation of nitric oxide [ 13 14 ] and is particularly prominent in older subjects with evidence of cardiovascular disease [ 15 ] , diabetes [ 16 ] , or obesity [ 17 ] . Interestingly, aging does not appear to effect endothelium independent vasodilation [ 10 14 ] .
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