Words similar to vasodilation
Example sentences for: vasodilation
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Altered vascular function in older individuals is evidenced as impaired endothelial function [ 8 9 10 ] , an altered ratio of endothelin receptors [ 11 ] , and/or altered reactivity of the smooth muscle to sympathetic activity [ 7 12 ] . Reduced endothelial function is related to impaired formation and decreased activation of nitric oxide [ 13 14 ] and is particularly prominent in older subjects with evidence of cardiovascular disease [ 15 ] , diabetes [ 16 ] , or obesity [ 17 ] . Interestingly, aging does not appear to effect endothelium independent vasodilation [ 10 14 ] .
Acetazolamide, on the other hand, was hypothesized to identify areas of decreased cerebral perfusion following maximal cerebral vasodilation in Fabry disease compared to controls.
The regulation of lumenal diameter in large arteries is accomplished through the maintenance of shear stress along the arterial wall [ 38 50 51 52 53 54 ] . As blood flow through an artery increases, shear is also increased, and the endothelium releases nitric oxide for vasodilation [ 55 ] . Chronically, the arterial wall will remodel to a larger diameter to accommodate the increased flow [ 38 ] . While we did not measure arterial flow through these iron deficient arteries, the enhanced inotropic compensation to iron deficiency, combined with the enlarged aortic diameter, leads us to suspect a flow dependent mechanism for remodeling.
A prolonged half time to recovery has been associated with a decreased nitric oxide and prostanoid production [ 8 ] and a loss of endothelium dependent vasodilation [ 9 ] . Reduced vascular reactivity is associated with many diseases that are associated with aging [ 15 16 17 ] . We did not find activity effects on half time to recovery.
The hyperemic cerebrovascular response to hypercapnia or acetazolamide is not inhibited by nitric oxide synthase inhibitors such as N G-monomethyl-L-arginine (L-NMMA) suggesting that NO does not mediate vasoreactivity [ 23 24 ] . The mechanism of acetazolamide vasodilation, beyond smooth muscle intracellular and extracellular acidosis due carbonic anhydrase inhibition, is unclear.
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