Words similar to valproic
Example sentences for: valproic
How can you use “valproic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Hair Color, Dose, Dose Duration, HPLC and FPIA Concentration per Segment, HPLC and FPIA Serum Concentration, Valproic Acid
Raw patient data for valproic acid analysis of hair and serum.
Valproic acid subcutaneously (SC) 1200 mg/kg (600 mg/cc) in two divided doses over 8 hours.
Valproic acid (VA) is a well-known teratogen in both animals and humans, with a 5-fold occurrence of spina bifida (SB) in pregnant women exposed to the drug [ 1 ] . The mechanism by which VA produces SB is unknown but inhibition of folic acid metabolism is one hypothesis [ 2 3 ] . Some investigators have brought the folic acid hypothesis into question by demonstrating that folic acid supplementation has no effect on VA exposed embryos in-vitro [ 4 5 ] . These studies suggest that another mechanism may be responsible for the production of SB by VA.
It has been well demonstrated that the major antiepileptic medications, phenytoin (PHT), carbamazepine (CBZ), and valproic acid (VPA) are readily recovered and quantified from hair specimens [ [ 22 23 24 25 26 27 28 29 ] ]. Thus, assessing the presence and quantity of these substances in hair may be a reliable marker for consumption, and provide an additional source of information to the physician who has historically relied only on the patient's self-reported compliance.