Example sentences for: valproic

How can you use “valproic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Hair Color, Dose, Dose Duration, HPLC and FPIA Concentration per Segment, HPLC and FPIA Serum Concentration, Valproic Acid

  • Raw patient data for valproic acid analysis of hair and serum.

  • Valproic acid subcutaneously (SC) 1200 mg/kg (600 mg/cc) in two divided doses over 8 hours.

  • Valproic acid (VA) is a well-known teratogen in both animals and humans, with a 5-fold occurrence of spina bifida (SB) in pregnant women exposed to the drug [ 1 ] . The mechanism by which VA produces SB is unknown but inhibition of folic acid metabolism is one hypothesis [ 2 3 ] . Some investigators have brought the folic acid hypothesis into question by demonstrating that folic acid supplementation has no effect on VA exposed embryos in-vitro [ 4 5 ] . These studies suggest that another mechanism may be responsible for the production of SB by VA.

  • It has been well demonstrated that the major antiepileptic medications, phenytoin (PHT), carbamazepine (CBZ), and valproic acid (VPA) are readily recovered and quantified from hair specimens [ [ 22 23 24 25 26 27 28 29 ] ]. Thus, assessing the presence and quantity of these substances in hair may be a reliable marker for consumption, and provide an additional source of information to the physician who has historically relied only on the patient's self-reported compliance.


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