Example sentences for: vacuolation

How can you use “vacuolation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The increased cell death induced by direct targeting of mutant SOD1 to mitochondria supports this possibility [ 27 ] . Interestingly, low levels (compared with the levels caused by mutant SOD1) of mitochondrial vacuolation can also be caused by expression of high levels of wild type SOD1 [ 7 13 15 41 ] , suggesting that the mitochondria-damaging property also exists in the wild type protein and this property strengthens by the mutations.

  • These observations indicate that neither MPT (expansion of matrix) nor autophagy (in which lysosomes participate) is responsible for mutant SOD1-induced mitochondrial vacuolation.

  • Nevertheless, the higher concentration of peroxisomes in and around vacuoles suggests that peroxisomes actively migrate to or proliferate in the vicinity of abnormal mitochondria and participate in the vacuolation process.

  • Our results as well as others' show that mitochondrial vacuolation provides an important window for examination of the mechanism whereby mutant SOD1 causes mitochondrial damage and motor neuron degeneration.

  • The absence of matrix expansion and the involvement of peroxisomes but not lysosomes together indicate that mutant SOD1-induced mitochondrial vacuolation is neither MPT nor autophagy.


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