Words similar to urothelium
Example sentences for: urothelium
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In the bladder, a relatively strong MIF staining was observed in the basal and intermediate layers of the urothelium of male and female rats confirming and extending our recent findings in male rats [ 10 11 ] . The superficial layer of the urothelium, on the other hand, contained relatively weak staining and areas devoid of MIF staining were often encountered.
The superficial layer of the urothelium showed slight MIF immunostaining but also showed areas that appeared clear of MIF staining (Fig 1B).
Intense MIF immunoreactivity in the urothelium was observed in the bladders of both male and female rats, confirming our previous observations [ 11 ] . The staining was most intense in the basal and intermediate layers of the urothelium (Fig.
In addition, the fibroblasts in the lamina propria, immediately under the urothelium also showed MIF immunoreactivity (Fig 1B).
These differences in epithelial MIF staining within the bladder and the prostate suggest a change in MIF synthesis as epithelia undergo differentiation as has been reported for the eye lens [ 17 ] . Basal cells in the urothelium undergo proliferation to give rise to the intermediate and superficial layers [ 18 ] and MIF expression was correlated with cell differentiation in the lens [ 17 ] . Therefore, it is possible that MIF is involved in cell differentiation in the urothelium and in other organs, as suggested by earlier investigations [ 16 17 ] . Alternatively, since the present study did not visualize MIF mRNA using in situ hybridization, it is possible that cells in the superficial layer of the urothelium synthesize MIF but release it more quickly than deeper epithelial cells.
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