Example sentences for: upstream

How can you use “upstream” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A strongly conserved stretch of unknown functional significance, EF(I/L)LLG(L/F), is located approximately ten amino acids upstream of the predicted first transmembrane region.

  • These analyses placed exon 1a upstream from exons 1b, b' and c and upstream from the 5' end of clone CH211-251J8.

  • However, the signal transduction pathway, MAPK, has been shown to control and be upstream of DNA-replication, transcription, and cell cycle pathways [ 52 53 54 ] . The mitogen-activated protein kinase (MAPK) pathway, consisting of the MAP kinase kinases (MKKs) 1 and 2, and extracellular signal-regulated kinases (ERKs) 1 and 2, which have been implicated in diverse cellular processes including proliferation, transformation, and cell differentiation [ 53 ] . The MAP kinase (MAPK) pathway has emerged as a crucial route between membrane-bound Ras and the nucleus.

  • The radial cloning method involves isolation of a set of nested overlapping fragments that extend from the gene-specific targeting hook to upstream or downstream Alu (or B1 ) positions in the gene of interest.

  • Interestingly, we also find that the full-length form of Rlk has a higher basal level of tyrosine phosphorylation and kinase activity than Itk when expressed in heterologous cells, consistent with potentially different localizations and upstream interactions (unpublished observations).


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