Example sentences for: upr

How can you use “upr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • If UPR were to gain control, it would buy up the remaining shares at market price.

  • Thus it appears that mefloquine induces an UPR similar to that induced by agents (e.g.

  • However, a potential connection between zinc and the UPR is the protein calreticulin, an ER protein-folding chaperone that acts on glycosylated proteins [ 61].

  • Genes that encode ER vesicle coat proteins ( SEC13, SEC21, SEC24, COP1, RET2, RET3 and others) were induced with other ER-specific genes in response to the UPR, as discussed above for cluster 58, but were also strongly repressed following long-term nitrogen and carbon starvation, along with hundreds of other genes that function in diverse aspects of secretion and protein synthesis (cluster 72).

  • Triggering of the UPR also results in the suppression of global protein synthesis, as PERK is activated and phosphorylates EIK2α, which can only interact with the appropriate ribosomal binding sites in an unphosphorylated state [ 11 12 ] . While the upregulated transcription of PERK is not required for its activation, it's over expression can lead to the enhanced phosphorylation (and therefore inactivity) of EIK2α [ 16 ] . Therefore, its up-regulation by mefloquine supports the hypothesis that the drug triggers an UPR.


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