Words similar to upr

Example sentences for: upr

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The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
In terms of the genes induced in the UPR (identified as the top 30 genes or so in cluster 58), the effects of diamide were most similar to those triggered by the reducing agent DTT (Figure 8d).
Hard as it may be to remember in a bull market, society doesn't get any richer when UPR exchanges its cash for Pennzoil's shares.
The clustering of KAR2 with both clusters of genes therefore reflects the known induction of the gene by Hac1p as part of the UPR but by Hsf1p following heat shock.
In response to defects in ER secretion, KAR2 is known to be induced by the transcription factor Hac1p as part of the unfolded protein response (UPR) [ 25, 26, 27, 28].