Words similar to upr
Example sentences for: upr
How can you use “upr” in a sentence? Here are some example sentences to help you improve your vocabulary:
If UPR were to gain control, it would buy up the remaining shares at market price.
Genes that encode ER vesicle coat proteins ( SEC13, SEC21, SEC24, COP1, RET2, RET3 and others) were induced with other ER-specific genes in response to the UPR, as discussed above for cluster 58, but were also strongly repressed following long-term nitrogen and carbon starvation, along with hundreds of other genes that function in diverse aspects of secretion and protein synthesis (cluster 72).
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
In contrast to this relationship, when the experiment clustering was performed on genes encoding ER-resident proteins, the effects of zinc starvation were most similar to those inflicted by DTT and diamide (Figure 8d), suggesting that zinc limitation may initiate the UPR.
The clustering of KAR2 with both clusters of genes therefore reflects the known induction of the gene by Hac1p as part of the UPR but by Hsf1p following heat shock.
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