Words similar to up-
Example sentences for: up-
How can you use “up-” in a sentence? Here are some example sentences to help you improve your vocabulary:
In hamsters, rats and mice, increases and decreases in bile acid absorption at the brush border membrane are mediated by an up- or down-regulation in IBAT gene transcription [ 33 34 ] . In several rodent species including mice, regulation of IBAT is clearly dependent on intraluminal bile acid concentrations and occurs via a negative feedback mechanism [ 33 34 35 ] . Feeding of bile acids suppresses transcription of IBAT mRNA and reduces IBAT protein abundance; feeding of the bile acid binder cholestyramine has the opposite effect.
Spearman's rank order correlation determined significant monotonic relationships that illuminate important connections between structural features in tissue elements and genes that have been reported as significantly up- or downregulated by CCl 4 treatment in previous studies [ 7 ] . Principal component analysis (PCA), as described in Materials and methods, was carried out to reduce the complexity of the data [ 15 ] and then to relate individual animals to specific phenotypic groups.
A cutoff of twofold up- or down-regulation has been chosen to define differential expression in most published studies [ 1, 2].
The pattern of gene expression (up- or down-regulation) was similar for the genes when the two methods of measurement were compared.
The top 20 ranking genes can be seen in Figure 12, where the genes known to be differentially regulated are shown in parentheses and up- or downregulation is shown in red or green, respectively.
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