Example sentences for: up-

How can you use “up-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In hamsters, rats and mice, increases and decreases in bile acid absorption at the brush border membrane are mediated by an up- or down-regulation in IBAT gene transcription [ 33 34 ] . In several rodent species including mice, regulation of IBAT is clearly dependent on intraluminal bile acid concentrations and occurs via a negative feedback mechanism [ 33 34 35 ] . Feeding of bile acids suppresses transcription of IBAT mRNA and reduces IBAT protein abundance; feeding of the bile acid binder cholestyramine has the opposite effect.

  • Spearman's rank order correlation determined significant monotonic relationships that illuminate important connections between structural features in tissue elements and genes that have been reported as significantly up- or downregulated by CCl 4 treatment in previous studies [ 7 ] . Principal component analysis (PCA), as described in Materials and methods, was carried out to reduce the complexity of the data [ 15 ] and then to relate individual animals to specific phenotypic groups.

  • A cutoff of twofold up- or down-regulation has been chosen to define differential expression in most published studies [ 1, 2].

  • The pattern of gene expression (up- or down-regulation) was similar for the genes when the two methods of measurement were compared.

  • The top 20 ranking genes can be seen in Figure 12, where the genes known to be differentially regulated are shown in parentheses and up- or downregulation is shown in red or green, respectively.


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