Example sentences for: up-

How can you use “up-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has a very dramatic expression profile in which hundreds of genes are rapidly (within minutes) up- or down-regulated.

  • A cutoff of twofold up- or down-regulation has been chosen to define differential expression in most published studies [ 1, 2].

  • Spearman's rank order correlation determined significant monotonic relationships that illuminate important connections between structural features in tissue elements and genes that have been reported as significantly up- or downregulated by CCl 4 treatment in previous studies [ 7 ] . Principal component analysis (PCA), as described in Materials and methods, was carried out to reduce the complexity of the data [ 15 ] and then to relate individual animals to specific phenotypic groups.

  • The third assumption is important for signal-dependent normalizations and is supported by the intuition that genes with 100 to 1,000 mRNA copies per cell will be no more or less biased toward up- or downregulation than genes with 10,000 to 100,000 copies per cell.

  • The p53 protein is known to function as a transcriptional regulator by either up- or down regulating target genes in response to different forms of cellular stress, including irradiation-induced DNA damage.


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