Words similar to unmodified
Example sentences for: unmodified
How can you use “unmodified” in a sentence? Here are some example sentences to help you improve your vocabulary:
As seen in Figure 1A, when only the unmodified NTPs are incorporated during the IVT, there is good separation of the individual nucleosides.
Repeat experiments with cRNA containing modified ATP supported the general specificity trend: unmodified ATP > 1:1 DAP:A > all DAP (data not shown).
An issue not evaluated in the present study, but one that has significant cost-saving potential, is the effect of reducing the length of unmodified oligonucleotides on microarray sensitivity.
Earlier studies have shown that DAP, in DNA fragments, can widen the minor groove, as detected by reactivity towards uranyl nitrate or susceptibility to Dnase cleavage [ 29 ] , and can relieve compressions in the minor groove associated with A-tracts [ 30 ] . In contrast, NMR and molecular modeling studies of an oligonucleotide duplex containing MeC have demonstrated that, while this duplex still has a B-DNA conformation, there are differences in the structural parameters and thermal stability relative to the unmodified duplex [ 31 ] . An earlier study also found, in two closely related octanucleotide duplexes, that although the methylated duplexes retained their B-DNA conformation, different structural and thermal stability effects were seen [ 32 ] . Although these studies have been carried out with DNA-DNA and not DNA-RNA duplexes, it is possible that MeC substitution may have different structural consequences than DAP substitution.
Immunization of guinea pigs with this modified variant results in an improved cross-reactive immune response to the unmodified parent enzyme in both antigen-specific IgG antibody production and T cell proliferative responses.
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