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Example sentences for: unmodified

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An additional metric of specificity on the Codelink bioarrays is the use of 54 negative control bacterial probes spotted in 4X redundancy, which were designed and empirically shown not to cross hybridize to human transcripts [ 6 ] . While the all DAP condition resulted in an increase in the hybridization intensity for three of the negative control probes, the 1:1 DAP:A condition produced lower background signals similar to those of the unmodified control (data not shown).
After hybridization, scatter plots of hybridization intensities were generated comparing those intensities generated from unmodified cRNA (control) to either the duplicate control hybridization or to intensities generated from cRNA where one of the modified NTPs was incorporated.
It was of interest that the unmodified protease induces antigen-specific IgG in the absence of detectable immunodominant T cell epitopes.
Notably, both modified and unmodified Pcu3p interacted with CSN subunits (Fig.
However, Figure 2Balso shows that full substitution of adenosine by DAP reduced the hybridization signals for many of the probes, generating a bowing towards the unmodified control condition and suggesting a duplex destabilizing effect of complete DAP substitution in certain sequence contexts [ 11 23 ] . On a global scale, such a high incidence of probes with reduced hybridization signals may limit the usefulness of the complete DAP substitution.