Words similar to unmethylated

Example sentences for: unmethylated

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Dong and co-workers also previously showed promoter methylation in 51% of CC [ 13 ] . DAPK is a positive mediator of the programmed cell death induced by gamma-interferon [ 21 ] . Loss of DAPK expression has been shown to occur in a number of human malignancies, primarily by promoter hypermethylation [ 11 ] . It has also been shown that loss of DAPK gene expression was associated with aggressive and metastatic phenotype in many tumor types [ 22 ] . In the present study, in addition to showing high frequency of promoter methylation of DAPK gene, we found a complete lack of expression in two of the methylated cell lines and four of 6 unmethylated cell lines.
The SW756 cell line with methylation and one of the two unmethylated cell lines showed reactivated expression upon treatment with 5-Aza-2' deoxycytidine or in combination with n-butyrate, but not with n-butyrate alone.
RARB gene showed either complete absence of or down regulated expression in all cell lines (6 methylated and 2 unmethylated).
Genomic DNA was treated with sodium bisulphite as previously described [ 33 ] . Placental DNA treated in vitro with Sss I methyltransferase (New England Biolabs, Beverly, MA) and similarly treated normal lymphocyte DNA were used as controls for methylated and unmethylated templates, respectively.
The unmethylated cell lines showed normal expression and the treatment had no effect on expression.