Example sentences for: unliganded

How can you use “unliganded” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data suggest that in the unliganded state, hypophosphorylated RARα can mimic the effects of RA on EGFR expression, ERK1 activity, and AP-1 protein levels.

  • In most cells, unliganded glucocorticoid receptors (GR) reside predominately in the cytoplasm, where they exist as a heteromeric complex comprised minimally of GR, 90-kDa and 70-kDa heat shock proteins (hsp90 and hsp70).

  • A peptide overlapping to the N-CoR ID1 motif (amino acids 2265-2291) that competes for N-CoR binding to unliganded TR and RAR [ 16 ] failed to compete for agonist-dependent ERβ interactions with N-CoR.

  • The unliganded LBD recognizes hydrophobic motifs, termed interaction domains (IDs), which are reiterated three times in N-CoR and twice in SMRT and conform to the consensus L/IXXIIXXXL [ 4 ] (see also [ 16 ] ). By contrast, the liganded LBD binds shorter hydrophobic motifs termed NR boxes that are reiterated several times within each coactivator and conform to the consensus LXXLL.

  • Unliganded NRs usually bind ID motifs (consensus L/IXXIIXXXL) in the N-CoR C-terminus.


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