Words similar to unglycosylated
Example sentences for: unglycosylated
How can you use “unglycosylated” in a sentence? Here are some example sentences to help you improve your vocabulary:
These data indicate that wild-type VR1 channels expressed in Xenopus oocytes are present in both unglycosylated and glycosylated forms and that the N-linked glycosylation occurs at position 604.
N-linked glycosylation is known to confer stability on many extracellular proteins [ 40 ] . Myocilin is similar to fibronectin (an extracellular matrix protein) in that both a glycosylated and unglycosylated form is secreted from the cell.
Several groups have shown that myocilin is glycosylated [ 10 16 17 18 19 20 21 ] whereas one group suggests that myocilin is not glycosylated [ 22 ] . In our hands, both an N-linked glycosylated (≈57-kDa) and unglycosylated (≈55-kDa) form of myocilin is detected in TM cell culture media [ 17 ] and aqueous humor [ 12 ] . The basis for both secretion and N-linked glycosylation of myocilin is part of the focus of this paper.
Through site-directed mutagenesis, we determined that the doublet represented unglycosylated and glycosylated forms of the VR1 subunit monomer and identified the glycosylation site as N604.
The unglycosylated form of fibronectin is more susceptible to proteolytic degradation than the glycosylated form [ 41 ] . It will be interesting to determine why two forms of myocilin are secreted in humans and what functionality, if any, N-linked glycosylation imparts on human vs. rabbit myocilin.
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