Example sentences for: unfolded

How can you use “unfolded” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • According to the proofreading model, in a wild type strain, SecE and SecY would reject the unfolded protein due to lack of a signal sequence.

  • Although the mutant LA57-N 102LTis predicted to be in an unfolded conformation in the bacterial cell, the protease protection assay was performed at 4°C.

  • His specialty lay in the supply of troops on the front and, as the Russian invasion unfolded, he grew horrified by Hitler's willingness to cut off entire divisions on a whim.

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.

  • When Diego unfolded his tilma in front of the bishop, the roses fell to the floor, and there on the tilma was an image of the Virgin Mary.


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