Words similar to unduplicated
Example sentences for: unduplicated
How can you use “unduplicated” in a sentence? Here are some example sentences to help you improve your vocabulary:
The second hypothesis holds that a gene duplication that leads to a new function is preceded by a period of 'gene sharing', such that the original, unduplicated gene encodes two distinct functions.
Proteins with a predicted signal peptide were more prevalent in Arabidopsis thaliana (35% of all paralogs versus 17% of all unduplicated genes from the proteome), Caenorhabditis elegans (41% among paralogs versus 31% among unduplicated genes) and Drosophila melanogaster (39% in paralogs versus 23% in orthologs) and predicted membrane proteins were more numerous in mammals (56% in paralogs versus 49% in unduplicated genes).
Each of these differences in the functional composition of the sets of paralogs and unduplicated genes were statistically highly significant (p < 0.0001, χ 2test).
The present observation that duplicated genes experience a substantial relaxation of selection compared to unduplicated genes is compatible with the traditional view that gene duplications make a major contribution to the evolution of new gene functions.
It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .
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