Example sentences for: underdominance

How can you use “underdominance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this report, we show that although population heterozygote advantage is compatible with allele-specific overdominance, it is also compatible with the opposite; i.e., population heterozygote advantage could arise in a population in which every heterozygote had a worse disease outcome than either of the corresponding homozygotes ("allele-specific underdominance").

  • We show that, depending on allele frequencies at the HLA locus of interest, population heterozygote advantage may occur when there is allele-specific overdominance, but may also occur under other conditions, including allele-specific underdominance.

  • It can also accommodate overdominance of the resistant alleles ( a > 1; b > d ; c > d ), in which each heterozygote does better than either corresponding homozygote, and underdominance, in which each heterozygote does worse than either corresponding homozygote ( a < 1; b < 1; c < d ). In this model, susceptibility and resistance are relative and simply refer respectively to lower and higher probabilities of favorable disease course, given infection.

  • Specifically, the conditions to observe population heterozygote advantage are broadest when allele-specific overdominance holds and become narrower as the underlying genetics becomes more "different" from overdominance of resistance (dominance -> additivity -> recessiveness -> underdominance).


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