Words similar to uncoupled
Example sentences for: uncoupled
How can you use “uncoupled” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tetrahymena telomerase and the binder/cutter appear to act concertedly in vivo , as if in a physical complex [ 48 49 ] . However, this contrasts with in vitro properties of the enzyme from exconjugants: 1.) it acts on non-telomeric primers [ 44 50 ] , and 2.) it apparently is no larger than the vegetative enzyme [ 44 ] . Furthermore, telomerase can act in the vegetative MAC of Paramecium , uncoupled from chromatid breakage [ 51 ] . It remains to be seen if a complex between telomerase and binder/cutter activity does exist.
It is noteworthy that, in yCCR4, these two parts of the protein (1-350 and 350-837) have well-defined and distinct functions, which can be uncoupled.
However, the ciliate literature is unclear about whether Tetrahymena telomerase might be able to act uncoupled from the action of the binder/cutter (see Introduction).
A similar vascular hyper-responsiveness has been noted in caveolin-1 knock-out mice [ 25 26 ] raising the possibility that the accumulation of Gb 3 results in over-activity of uncoupled endothelial nitric oxide synthase within endothelial cell caveolae generating superoxide and other reactive oxygen species [ 27 ] . The latter may have a vasodilatatory effect [ 28 ] . Predominance of vascular abnormalities in the vertebro-basilar system in Fabry disease suggests fundamental biologic differences between the anterior and the posterior circulation.
However, even if cases occur in which altered RP transcript expression does not lead to changes in expression of the corresponding protein, our and others' findings regarding selective regulation of RP transcripts would then raise the interesting issue as to why, and the mechanism by which, transcript and protein expression are uncoupled.
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