Words similar to uncharacterised
Example sentences for: uncharacterised
How can you use “uncharacterised” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, this report serves to clarify the activation profiles of many previously uncharacterised ligands in cells expressing only μ opioid receptors, thus leading to a better understanding of the mechanism of action of these drugs.
To locate exon-intron positions in previously uncharacterised genes (or predicted genes) that have not yet been associated with cDNAs, we performed spliced alignment, maintaining maximum similarity between homologues, as described in Methods.
Collection and assembly of previously uncharacterised runx genes
Runx1 orthologues contain 3. CiRunt contains 5 exons downstream of the Runt domain, while CeRun contains 4. In vertebrates at least, the multiplicity of downstream exons is reflected in a large variety of alternatively spliced transcripts that give rise to multiple protein isoforms that differ in the C-terminal sequences appended to the Runt domain [ 12 13 ] . It is important to note that the C-terminal exon of all Runx genes identified to date encodes the amino acid sequence VWRPY (or the functionally equivalent IWRPF in the case of C. elegans ), which acts as a recruitment motif for the co-repressor Groucho/TLE [ 3 ] . This motif is at the C-terminus within the 3'-most exon of all of the genes, possibly with the exception of CiRunt (where the open reading frame apparently continues beyond the VWRPY in the genome sequence), and was used in our analysis to identify the C-terminal exons of previously uncharacterised Runx genes.
The data presented in this report agree with available published data, thus establishing that the methods used were valid and could be successfully used to provide useful data for previously uncharacterised ligands.
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