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Example sentences for: typing
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For over a decade the idea of representing biological sequences in a continuous coordinate space has maintained its appeal but not been fully realized [ 1 2 3 ] . The basic idea is that sequences of symbols, such as nucleotides in genomes, aminoacids in proteomes, repeated sequences in MLST [Multi Locus Sequence Typing, 4], words in languages or letters in words, would define trajectories in this continuous space conserving the statistical properties of the original sequences [ 3 5 6 7 8 9 ] . Accordingly, the coordinate position of each unit would uniquely encode for both its identity and its context, i.e. the identity of its neighbors [ 10 ] . Ideally, the position should be scale-independent, such that the extraction of the encompassing sequence can be performed with any resolution, leading to an oligomer of arbitrary length.
It seems likely that, as in the HLA region [ 32], there will be a limited number of ancestral haplotypes in the 1q41 region, and that these ancestral haplotypes will be identifiable by typing a dense map of microsatellites.
This map is approximately 12 times the length of an F2 map of chromosome 1, and just over three times the length expected of an RI map of chromosome 1. The accumulation of typing errors has led to efforts to reconstitute maps using curated subsets of markers for which genotypes can be adequately and independently verified.
Author 2 (HAP) participated in the collection of tumors, clinical follow-up data, and performed HPV typing.
HFE mutation analysis was performed as previously described [ 23 ] . A and B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in probands [ 23 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 25 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 26 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
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