Words similar to twofold
Example sentences for: twofold
How can you use “twofold” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our calculations reveal that even if a hypothetical disease allele gave a 10-fold increased risk, out of the 132 possible pairs of SNPs, in 92 of them (70%), the marker would show a relative risk of less than twofold.
Accuracy was defined as the fraction of computed fold-changes that were accurate within twofold, and determined for assumed levels of spike-skew from 10-40% (percentage is the ratio of standard deviation (SD) to mean of the random spike-skew term in the simulation).
In heart versus brain comparisons, oligonucleotide probes, like their cDNA probe counterparts, could reproducibly discern differences in mRNA populations as low as twofold (namely, 14-3-3 protein gamma) and as high as around 90-fold (namely, creatine kinase).
The use of a higher criterion (that is, threefold) excluded some genes, such as those for MCP-1 and ICAM-1, which are known to be regulated in the acute phase of allergen challenge [ 15, 16]; on the other hand, a lower criterion, such as twofold, increased the probability of false-positive genes and lack of confirmation by RT-PCR (see Validation of the microarray gene expression, below).
The goals of this work were twofold: to use cDNA microarrays to characterize the primary response of intestinal epithelial cells to a well-studied intracellular pathogen, L. monocytogenes , and to try to identify host gene-expression programs which are induced by specific stages of the infection by comparing the wild-type expression profile to that of mutants which are either incapable of intracellular growth and thus avirulent, or which cannot initiate actin polymerization in host cell cytoplasm.
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