Example sentences for: tumor-specific

How can you use “tumor-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Like many of the adoptive transfers of tumor-specific T cells in clinical cases [ 2 3 4 5 6 7 ] , no significant lymphocyte infiltration into solid tumor was detected [ 22 ] . If, however, Rip1-Tag5 mice were treated with lethal radiation and subsequent reconstitution with bone marrow from RAG1 deficient mice prior to T cell transfer, modest lymphocyte infiltration into solid tumors was noted [ 22 ] ; however, this study did not assess the efficacy of that response.

  • Previous studies have indicated that solid tumors can be resistant to the infiltration of tumor-specific T cells.

  • For example, in the related Rip1-Tag5 model, the vascular addressins GlyCAM-1 and MAdCAM-1 are expressed in pre-malignant islets, but down-regulated in solid tumors; their downregulation coincides with lack of infiltration in this model of spontaneous anti-tumor immunity [ 19 ] . It is possible that sub-lethal radiation is altering the expression of endothelial adhesion molecules allowing binding and extravasation of activated tumor-specific lymphocytes.

  • While the underlying mechanisms remain unknown, it is evident that a combination of sub-lethal radiation and the transfer of tumor-specific CD4 +lymphocytes can have a synergistic effect on tumor regression.

  • In this approach, an enzyme is conjugated to a tumor-specific antibody.


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