Words similar to tumor-specific
Example sentences for: tumor-specific
How can you use “tumor-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:
Like many of the adoptive transfers of tumor-specific T cells in clinical cases [ 2 3 4 5 6 7 ] , no significant lymphocyte infiltration into solid tumor was detected [ 22 ] . If, however, Rip1-Tag5 mice were treated with lethal radiation and subsequent reconstitution with bone marrow from RAG1 deficient mice prior to T cell transfer, modest lymphocyte infiltration into solid tumors was noted [ 22 ] ; however, this study did not assess the efficacy of that response.
Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.
While the underlying mechanisms remain unknown, it is evident that a combination of sub-lethal radiation and the transfer of tumor-specific CD4 +lymphocytes can have a synergistic effect on tumor regression.
Third, radiation may alter the biophysical structures of tumors, which in some tumors has the capability to impair the infiltration or function of tumor-specific T cells.
A recent study has suggested that tumor-specific, CD4 +T cells can exert anti-tumor effects by inhibiting angiogenesis via release of IFN-γ [ 11 ] . Thus, the "white" tumors noted in the current study may be indicative of angiogenic inhibition by the infiltrating tumor-specific, CD4 +T cells, and such inhibition may be relevant to the observed efficacy.
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