Words similar to tumor-specific
Example sentences for: tumor-specific
How can you use “tumor-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this approach, an enzyme is conjugated to a tumor-specific antibody.
A recent study has suggested that tumor-specific, CD4 +T cells can exert anti-tumor effects by inhibiting angiogenesis via release of IFN-γ [ 11 ] . Thus, the "white" tumors noted in the current study may be indicative of angiogenic inhibition by the infiltrating tumor-specific, CD4 +T cells, and such inhibition may be relevant to the observed efficacy.
For example, in the related Rip1-Tag5 model, the vascular addressins GlyCAM-1 and MAdCAM-1 are expressed in pre-malignant islets, but down-regulated in solid tumors; their downregulation coincides with lack of infiltration in this model of spontaneous anti-tumor immunity [ 19 ] . It is possible that sub-lethal radiation is altering the expression of endothelial adhesion molecules allowing binding and extravasation of activated tumor-specific lymphocytes.
Previous studies have indicated that solid tumors can be resistant to the infiltration of tumor-specific T cells.
Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.
Loading...