Words similar to trma
Example sentences for: trma
How can you use “trma” in a sentence? Here are some example sentences to help you improve your vocabulary:
thiamine diphosphate (ThDP); thiamine-responsive megaloblastic anemia (TRMA)
Surprisingly, mitochondria derived from TRMA lymphoblasts lacked the high affinity uptake of thiamine.
Although we found a lack of mitochondrial uptake of thiamine in TRMA cells, our finding of an intact, high affinity ThDP transport mechanism for TRMA mitochondria is consistent with and offers an explanation for such an interpretation.
Interestingly, ThDP-utilizing enzymes in mitochondria are much less affected (as revealed by loss of activity) upon progressive depletion of thiamine available to TRMA cells than are ThDP-utilizing enzymes of the cytosol [ 6 ] . For these reasons, we have examined the uptake of thiamine and especially ThDP by mitochondria from several human cell types, including cells from TRMA patients.
Although western analysis using anti-human transporter (that is mutated in TRMA individuals) antiserum supports this interpretation, further experiments need to be carried out to substantiate the suggestion of a shared thiamine transporter between these two membrane systems.