Words similar to transphosphorylation
Example sentences for: transphosphorylation
How can you use “transphosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:
These results demonstrate that opioid-mediated ERK activation occurs independently of EGFR transphosphorylation, and that the tyrosine-phosphorylated δ-OR may serve as the primary scaffold.
However, the Src inhibitor, PP1 or the expression of a dominant-negative Src mutant, will reduce GPCR-mediated transphosphorylation of the EGFR and GPCR-mediated ERK activation to varying degrees (partial to total), suggesting that at least two different tyrosine kinases can be involved [ 18 ] . Src was found to co-immunoprecipitate with the phosphorylated EGFR in COS-7 cells exposed to either LPA or EGF [ 14 ] . These authors reported that the autophosphorylation of Y350 in the EGFR does not occur after LPA exposure, suggesting that c-Src is the principal tyrosine kinase in this instance and not the EGFR's intrinsic tyrosine kinase.
In this report, we have presented considerable evidence that δ-ORs and EGFRs activate ERKs, independently, without the need for transphosphorylation of a co-expressed RTK.
However, transphosphorylation of the EGFR after OR activation has not been reported.
, [ 14 ] have demonstrated that stimulation of LPAR (G i/q -coupled) and β 2 -ARs (G s -coupled), respectively, results in the "transactivation /transphosphorylation" of co-expressed EGFRs.