Words similar to transferases
Example sentences for: transferases
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Genes identified using enrichment or screening protocols include Rv2962c and Rv2958c (probable glucuronsyl transferases), Rv2220 (glutamine synthetase A1), Rv3913-Rv3914 (thioredoxin, thioredoxin reductase) and Rv2416c ( eis, unknown function) [ 14 15 22 29 ] . By screening insertional mutants of M. smegmatis, Lagier et al [ 30 ] isolated 8 mutants with impaired ability to survive in human peripheral blood monocyte-derived macrophages and identified the M. tuberculosis gene corresponding the mutated M. smegmatis gene for five of them.
We have used PSI-BLAST to find orthologs of enzymes that use glutathione (including glutaredoxins, glutathione- S -transferases, glutathione reductases and glutathione peroxidases) in both bacteria and eukaryotes (data not shown).
Histidine triad (HIT) enzymes are a superfamily of nucleotide hydrolases and transferases that contain a catalytic motif related to the sequence HisφHisφHisφφ (where φ represents a hydrophobic amino acid) and act on substrates containing a nucleoside monophosphate [ 24].
Analogous active sites, that coordinate two metal ions, are observed in domains with similar activities, such as the classical adenylyl/guanylyl cyclases, family B DNA polymerases, pol-β fold nucleotidyl transferases, and triphosphatases or phosphoesterases of the HD and DHH superfamilies [ 11 15 19 20 ] . Consistent with these observations, both CyaB and ThTPase have been shown to require Mg 2+ions for their nucleotide cyclase and phosphatase activities [ 16 17 ] .
The classical adenylyl cyclases, guanylyl cyclases and the GGDEF (diguanylate cyclase) domains share the catalytic palm domain with the family B DNA polymerases, reverse transcriptases, viral RNA dependent RNA polymerases and eukaryote-type primases [ 4 13 14 ] . The pathogenic adenylyl cyclases of several bacteria and the CyaA-like proteobacteria adenylyl cyclases are extremely divergent versions of the catalytic domain seen in the Pol-β family of nucleotidyl transferases [ 15 ] (also see SCOP database: http://scop.mrc-lmb.cam.ac.uk/scop/).
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