Words similar to transcellular
Example sentences for: transcellular
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During transcellular calcium transport across the absorptive enterocyte, calcium must pass across an apical brush border membrane, then transverse the interior of the cell, and exit against an electrochemical gradient across the basolateral membrane.
These epithelial calcium channel genes are products of evolutionary local gene duplication found on chromosome 7 and represent a new family of Ca-selective ion channels involved in active Ca (re)absorption [ 12 ] . Furthermore, it has been suggested that the control of the number of active channels at the cell surface is critical for regulation of active calcium transport and that the epithelial calcium channel could confer the rate-limiting step in transcellular calcium transport [ 13 ] .
The coordinated vitamin D-dependent induction of the cytosolic calcium-binding protein calbindin D could serve this function when the need for transcellular calcium flux is high by acting directly or indirectly as a molecular sponge and selectively removing calcium ions from the CaT1 channel and/or to buffer increases in intracellular calcium, thereby preventing premature inactivation of this I CRAC channel [ 15 ] . Calbindin D could also play its traditionally conceived role as a calcium chaperone protein to facilitate the transfer of calcium through the cytosol [ 32 ] and perhaps delivery of Ca ++to the basolateral ATP-dependent calcium pump for extrusion out of the enterocyte [ 33 ] .
Intracellular bile acid binding proteins have been postulated to participate in the transcellular transport as well as to buffer against the cytotoxic effects of bile acids.
We have previously reported that it takes from 12-16 h following 1,25-dihydroxyvitamin D treatment of Caco-2 cells to first appreciate an increase in saturable transcellular calcium transport [ 19 ] . This temporal response is similar to the 8-16 h observed for the achievement of maximal rates of intestinal calcium absorption in vivo following 1,25-dihydroxyvitamin D treatment of vitamin D-deficient chickens [ 28 ] . Future studies of the time course of CaT1 protein expression and localization of this protein to the brush border will be necessary to confirm this point, but must await the development of a suitable CaT1 antibody.
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