Words similar to trans-activates

Example sentences for: trans-activates

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Androgen exerts its biologic effects by binding to and activation of androgen receptor (AR) that trans-activates target genes through androgen responsive element (ARE) in the promoter of target genes [ 15 ] . In human breast cancer cells the effectiveness of retinoids in cell growth suppression was dictated by the presence of RAR [ 16 ] . Estrogen regulation of the expression of RAR α was mediated by interactions between estrogen receptor (ER) and estrogen responsive element (ERE) in the promoter of RAR α gene [ 17 ] . Because the DNA binding domains of steroid receptors including AR and ER are highly homologous, we postulated that similar mechanisms might also mediate the effect of androgen on RAR genes in prostate cells.