Words similar to traf
Example sentences for: traf
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Behçet's disease is an autoimmune disorder characterized by a systemic vasculitis that affects the joints, all sizes and types of blood vessels, the lungs, the central nervous system, and the gastrointestinal tract [ 38 ] . There is evidence for linkage with markers spanning nearly 28 Mb of 6p with JA04 in the middle [ 18 ] . Candidate genes for Behçet's would include those expressed in lymphocytes or perhaps bone marrow such as AP3 and FLJ12671 and other immune related genes such as TRAF and RU2AS.
These effects were irreversible and not caused by inhibition of proximal signaling at the level of STAT1 or TRAF6, suggesting that resistance to IFN-γ is caused by a complex differentiation program specifying the osteoclast fate.
Since it is well established that RANK signaling is mediated primarily through TRAF6 [ 35 ] and that IFN-γ signaling is mediated primarily through STAT1 [ 36 37 ] , we examined their expression by western blot.
Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.
We failed to observe significant degradation of TRAF6 after stimulation with IFN-γ or RANKL in short-term or long-term cultures (Fig.
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