Words similar to traf
Example sentences for: traf
How can you use “traf” in a sentence? Here are some example sentences to help you improve your vocabulary:
These effects were irreversible and not caused by inhibition of proximal signaling at the level of STAT1 or TRAF6, suggesting that resistance to IFN-γ is caused by a complex differentiation program specifying the osteoclast fate.
These results show that late pre-osteoclasts are capable of signaling via JAK-STAT1, and suggest that signaling events distal to TRAF6 and STAT1 modulate the resistance of these cells to IFN-γ.
While this discrepancy could be explained by the possibility that RAW cells represent a stage of pre-osteoclast differentiation that is not sensitive to IFN-γ-mediated TRAF6 degradation, the present studies clearly indicate that IFN-γ can inhibit osteoclastogenesis via a completely different mechanism.
Thirteen genes were previously mapped to this region (RU2AS, MRS2L, GPLD1, SSADH, KIAA0319, TRAF, HT012, FLJ12619, Geminin, KIAA0386, Cyclophilin A, CMAH, and NUP50) and are present on the NCBI accession view (NT_017021) of 6p21.
Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.
Loading...