Words similar to traf

Example sentences for: traf

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These results show that late pre-osteoclasts are capable of signaling via JAK-STAT1, and suggest that signaling events distal to TRAF6 and STAT1 modulate the resistance of these cells to IFN-γ.
Intergenic distances range from less than 1 Kb (KIAA0319 and TRAF) to 110 Kb (HNRPA1 and P24).
We failed to observe significant degradation of TRAF6 after stimulation with IFN-γ or RANKL in short-term or long-term cultures (Fig.
Since it is well established that RANK signaling is mediated primarily through TRAF6 [ 35 ] and that IFN-γ signaling is mediated primarily through STAT1 [ 36 37 ] , we examined their expression by western blot.
Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.