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Example sentences for: towne
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In another study, Newkirk and coworkers also observed that a recombinant gB vaccine, which expressed the gB protein of the Towne vaccine, induced antibodies to CMV gB when administered to mice, suggesting that CMV gB induces antibodies crossreactive to U1-70 kD [ 13 ] . If this is the case, it predicts a correlation between levels of antibodies to gB and U1-70 kD in sera.
We failed to detect antibodies to either Sm or RNP in individuals infected with wild-type CMV or in eight individuals vaccinated with the Towne strain of CMV.
The gB antigen used in this assay was a recombinant derivative of human CMV strain Towne gB produced as a secreted protein in Chinese hamster ovary cells [ 21 ] . The recombinant gB includes amino acids 1-676 of the extracellular domain.
The strain used in this study, AD169, and the Towne strains were both used to develop vaccines [ 49 ] . Differences in infectivity have been observed between 2 of the same strains of CMV and this may be attributed to the deletion or mutation of certain tropism genes upon extensive serial propagation [ 50 51 ] . Clinical isolates (wild-type CMV) can carry more than 220 genes, and some of these genes can be lost by deletion and/or rearrangement during laboratory passage [ 50 ] . The AD169 strain used in this study has been passaged many times and because of these variations observed among the CMV strains, this may partly account for the low infectivity observed in the BJAB-B1 and P3HR-1 cells.
Also included were postimmunization serial sera from eight normal healthy women who had received 6000 plaque forming units of the live attenuated Towne vaccine as a single subcutaneous injection.
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