Words similar to towne
Example sentences for: towne
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We failed to detect antibodies to either Sm or RNP in individuals infected with wild-type CMV or in eight individuals vaccinated with the Towne strain of CMV.
The strain used in this study, AD169, and the Towne strains were both used to develop vaccines [ 49 ] . Differences in infectivity have been observed between 2 of the same strains of CMV and this may be attributed to the deletion or mutation of certain tropism genes upon extensive serial propagation [ 50 51 ] . Clinical isolates (wild-type CMV) can carry more than 220 genes, and some of these genes can be lost by deletion and/or rearrangement during laboratory passage [ 50 ] . The AD169 strain used in this study has been passaged many times and because of these variations observed among the CMV strains, this may partly account for the low infectivity observed in the BJAB-B1 and P3HR-1 cells.
These were preimmunization screening sera from 80 normal healthy adult females who volunteered for a Towne vaccine study.
The gB antigen used in this assay was a recombinant derivative of human CMV strain Towne gB produced as a secreted protein in Chinese hamster ovary cells [ 21 ] . The recombinant gB includes amino acids 1-676 of the extracellular domain.
To confirm the findings of Newkirk et al . [ 14 ] , we evaluated sera from individuals either naturally infected with CMV or immunized with the live attenuated Towne strain of CMV for the presence of antibodies to three antigens: Sm, RNP, and U1-70 kD.