Example sentences for: top-down

How can you use “top-down” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • ‘The distinctions I make are much more between top-down and bottom-up.

  • Thus, the traditional model of top-down distribution of funds must be changed, and this may be difficult.

  • However, to encourage coherence within the gene clusters, it can be better to use a partially supervised criterion, which does use principal components and top-down shaving.

  • Progress in digital microscopy has allowed quantitative image analysis to generate data that objectively and completely describe tissue phenotype, free of observer disagreement [ 13 ] , and with the potential to detect subtle changes that are undetectable to the human eye [ 14 ] . Tissue histomorphometric profiles in EMeRGE are correlated statistically with gene-expression profiles, characterizing each sample through both top-down phenotypic information and complementary bottom-up genomic data.

  • As a spur to improvements in the system, given the slow pace of top-down efforts at reform, it seems worth trying out in different ways, but it shouldn't be considered a cure-all, especially for the worst-off schools.


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