Example sentences for: toll-like

How can you use “toll-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In light of recent developments in understanding the biology of Toll-like receptors, the NFκB-dominated responses we observe fit well within a model in which undifferentiated, subconfluent Caco-2 cells can recognize Gram-positive cell-surface moieties and induce what is termed an 'innate immune response'.

  • In Drosophila , the prototypic homolog of the mammalian Toll-like receptors (Toll) defends against fungal infection [ 18], whereas the protein 18-wheeler defends against bacterial infection [ 19].

  • Since lymphocytes lack Toll-like receptor 4 and express little or no CD14 [ 33 ] , we conclude that the induction of TTP in these cells was occurring indirectly, presumably through stimulation with TNF, although other cytokines, including IL-1, IL-6, and IL-8, could contribute to this response.

  • We recently identified the Lps locus through positional cloning [ 10] and showed that the LPS-resistance phenotype was caused by defects in the Toll-like receptor 4 gene ( Tlr4 ) [ 11].

  • The absence of LPS-signal transducers (CD14, Toll-like receptor 4) on most lymphocytes relative to monocytes and neutrophils may account for this altered expression [ 42 43 ] . Since lymphocytes express TNF receptors and TNF itself can induce TTP mRNA expression [ 38 ] , these data are consistent with the interpretation that TTP induction in lymphocytes is transduced not by LPS binding, but by TNF produced by monocytes and/or neutrophils acting on lymphocytes.


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